The Engineered Cellular Microenvironments and Microstructures (ECM2) lab, in the Department of Chemical and Biomolecular Engineering at the University of lllinois, develops tools to fabricate, characterize, model, and use three-dimensional biomaterials for a wide range of tissue engineering and regenerative medicine applications. A central paradigm of our work is the development of engineered microstructures that allow modulation of extrinsic regulators of cell behavior in defined increments, and their use to identify material properties to improve construct bioactivity or to induce desired cell behaviors at the single cell or cell population levels. Our research thrusts are primarily focused on developing materials and methods that can be applied to clinically-based problems, are of interest to biomaterial and biotechnological companies, and emphasize multi-disciplinary, collaborative interactions with colleagues in both academia and industry.
Dr. Harley receives the 2014 Society for Biomaterials Young Investigator Award!
Brendan will be officially honored at the 2014 Soc. for Biomaterials meeting in Denver in April, but we are excited to announce... [more]
We're regenerating (kind of) - Congrats to Sara and Jose
Congratulations to Sara Pedron Haba and her husband Jose for the arrival of Alonso. Looking forward to meeting him... [more]
Bhushan's recent article featured in Materials Views
Our recent publication in Advanced Healthcare Materials on microfluidic approaches to modulate the hematopoietic stem cell envi... [more]
Best wishes to Dr. Caliari!
Many thanks and best wishes to our first graduate, Dr. Steven Caliari, on his last day with us. Steven joined our group back in... [more]
New article with Cunningham group in Analyst
Congratulations to Sunny Choi and Dr. Harley for acceptance of their article, “Photonic crystal enhanced microscopy for imagi... [more]
2013. B.P. Mahadik, T.D. Wheeler, L.J. Skertich, P.J. Kenis, B.A. Harley*, Microfluidic generation of gradient hydrogels to modulate hematopoietic stem cell culture environment,’ Adv. Healthcare Matls., 2013, Adv Healthcare Matls [DOI]
2013. W. Chen, K.D. Long, M. Lu, V. Chaudhery, H. Yu, J.S. Choi, J. Polans, Y. Zhuo, B.A. Harley, B.T. Cunningham*, Photonic crystal enhanced microscopy for imaging of live cell adhesion, Analyst [DOI]
2013. D.W. Weisgerber, D.O. Kelkhoff, S.R. Caliari, B.A. Harley*, The impact of discrete compartments of a multi-compartment collagen-GAG scaffold on overall construct biophysical properties, J Mech Behav Biomed Matls [DOI]
Brendan Harley, Sc.D. University of Illinois at Urbana-Champaign Dept. of Chemical and Biomolecular Engineering 110 Roger Adams Lab, MC-712, Box C-3 600 S. Mathews Avenue Urbana, IL 61801 USA Phone: 217.244.7112 Fax: 217.333.5052 Email: bharley@Illinois.edu