Harley Lab Research Overview

The Engineered Cellular Microenvironments and Microstructures (ECM2) lab, in the Department of Chemical and Biomolecular Engineering at the University of lllinois, develops tools to fabricate, characterize, model, and use three-dimensional biomaterials for a wide range of tissue engineering and regenerative medicine applications. A central paradigm of our work is the development of engineered microstructures that allow modulation of extrinsic regulators of cell behavior in defined increments, and their use to identify material properties to improve construct bioactivity or to induce desired cell behaviors at the single cell or cell population levels. Our research thrusts are primarily focused on developing materials and methods that can be applied to clinically-based problems, are of interest to biomaterial and biotechnological companies, and emphasize multi-disciplinary, collaborative interactions with colleagues in both academia and industry.

Lab News

Jul 2014 Dr. Harley receives Mayo-Illinois Alliance Challenge Grant
Dr. Harley has received a two-year grant from the Mayo-Illinois Alliance entitled 'Chip-based engineered tumor microenvironment... [more]

Jul 2014 Benzophenone photolithography project accepted by Biomaterials!
Congratulations to Laura Mozdzen as well as our collaborators Jess Banks and Ryan Bailey for the acceptance of our new article... [more]

Jul 2014 Congrats Dr. Mahadik!
Many congratulations to Bhushan Mahadik for his successful doctoral defense today, 'Hydrogel platform to investigate the coordi... [more]

Jul 2014 Jackie's biofouling paper accepted at Biomaterials Science!
Congrats to current trainee Jackie Pence, along with lab alum Emily Gonnerman (MS, 2011) and collaborator Ryan Bailey, for acce... [more]

Jul 2014 VEGF photopatterning project accepted by Acta Biomaterialia!
Congratulations to current trainees Jackie Pence and Dan Weisgerber, as well as our collaborators at U. Illinois (Ryan Bailey w... [more]

Recent Publications

2014. S.R. Caliari, L.C. Mozdzen, O.E. Armitage, M.L. Oyen, B.A. Harley*, Periodically-perforated core-shell collagen biomaterials balance cell infiltration, bioactivity, and mechanical properties, J Biomed Mater Res A [DOI]

2014. S.R. Caliari, B.A. Harley*, Structural and biochemical modification of a collagen scaffold to selectively enhance MSC tenogenic, chondrogenic, and osteogenic differentiation, Adv Healthc Matls [DOI]

2014. S.R. Caliari, B.A. Harley*, Collagen-GAG scaffold biophysical properties bias MSC lineage choice in the presence of mixed soluble signals [DOI]


Brendan Harley, Sc.D.
University of Illinois
at Urbana-Champaign
Dept. of Chemical and
Biomolecular Engineering

110 Roger Adams Lab, MC-712, Box C-3
600 S. Mathews Avenue
Urbana, IL 61801 USA

Phone: 217.244.7112
Fax: 217.333.5052
Email: bharley@Illinois.edu