Burke Laboratories @ UIUC

For a free electronic reprint of any Burke Group publication, please email Calgary Martin at burkeassistant@gmail.com.

  1. Davis, S.A.; Della Ripa, L.A.; Hu, L.; Cioffi, A.G.; Rienstra, C.M.; Burke, M.D. "C3-OH of Amphotericin B Plays an Important Role in Ion Conductance" Journal of the American Chemical Society 2015, 137, 15102-15104.
    [abstract], [pdf], [supp info]


  1. Endo, M.M.; Cioffi, A.G.; Burke, M.D. "Our Path to Less Toxic Amphotericins" Synlett 2015, ASAP. Recipient of the Thieme IUPAC Prize in Synthetic Organic Chemistry.
    [abstract], [pdf]


  1. Cioffi, A. G.; Hou, J.; Grillo, A. S.; Diaz, K. A.; Burke, M. D. "Restored physiology in protein-deficient yeast by a small molecule channel" Journal of the American Chemical Society 2015137, 10096–10099.
    [abstract], [pdf], [supp info]

  • Highlighted in Cystic Fibrosis News, "New Cystic Fibrosis Research Focused on Small Molecules Interaction with Yeast".
  • Highlighted in Lung Disease News, "Researchers Investigate a Better Way to Address the Root Cause of Cystic Fibrosis"
  • Highlighted in Medical News Today, "Cystic fibrosis: yeast study may address root cause"
  • Highlighted in News Medical, "Researchers explore better way to address the root cause of cystic fibrosis"
  • Highlighted in Doctor Pulse, "Therapeutic Approach to Tackle the Cause Cystic Fibrosis"
  • Also highlighted in Phys.org, Science Daily, and Eureka Alert!, "Tackling the Root Cause of Cystic Fibrosis"
  • For highlights on the molecular prosthetics approach, see: Science, "The Synthesis Machine"; U.S. News and World Report, "'Molecular Prosthetics' May Give New Hope for Incurable Diseases"; and Chemistry and Industry, "Molecular Prosthetics"
  • Click here to watch a webinar with Marty, on making molecular prosthetics with the small molecule synthesizer
  1. Li, J.; Grillo, A. S; Burke, M. D. "From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks" Accounts of Chemical Research 201548, 2297–2307.
    [abstract], [pdf]  


  1. Davis, S. A.; Vincent, B. M.; Endo, M. M.; Whitesell, L.; Marchillo, K.; Andes, D. R.; Lindquist, S.; Burke, M. D. "Nontoxic Antimicrobials that Evade Drug Resistance" Nature Chemical Biology 2015, 11, 481-487.
    [abstract], [pdf], [supp info]

  1. Li, J.; Ballmer, S. G.; Gillis, E. P.; Fujii, S.; Schmidt, M. J.; Palazzolo, A. M. E.; Lehmann, J. W.; Morehouse, G. F.; Burke, M. D. "Synthesis of Many Different Types of Organic Small Molecules Using One Automated Process" Science 2015, 347, 1221-1226.
    [abstract], [pdf], [supp info]

  1. Woerly, E. M.; Roy, J.; Burke, M. D. "Synthesis of Most Polyene Natural Product Motifs Using Just Twelve Building Blocks and One Coupling Reaction" Nature Chemistry 2014, 6, 484-491.
    [abstract], [pdf], [supp info]

  1. Anderson, T. M.; Clay, M. C.; Cioffi, A. G.; Diaz, K. A.; Hisao, G. S.; Tuttle, M. D.; Nieuwkoop, A. J.; Comellas, G.; Wang, S.; Uno, B. E.; Wildeman, E. L.; Maryum, N.; Gonen, T.; Rienstra, C. M.; Burke, M. D. "Amphotericin Forms an Extramembranous and Fungicidal Sterol Sponge" Nature Chemical Biology 2014, 10, 400-406.
    [abstract], [pdf], [supp info]

  • Highlighted in Nature Chemical Biology, "A Sponge against Fungal Infections".
  • Highlighted by Illinois News describing the elucidation of amphotericin's biological activity.
  • Also highlighted in Science Newsline, Phys.org, Science Daily, Health Canal, and Chemistry Views.
  1. Wilcock, B. C.; Endo, M. M.; Uno, B. E.; Burke, M. D. "C2'-OH of Amphotericin B Plays an Important Role in Binding the Primary Sterol of Human Cells but Not Yeast Cells" Journal of the American Chemical Society 2013, 135, 8488-8491.
    [abstract], [pdf], [supp info]

  • Highlighted in C&EN News describing its potential as "A Less Toxic Antifungal Agent".
  1. Woerly, E. M.; Miller, J. E.; Burke, M. D. "(1-Bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis" Tetrahedron Special Issue in Honor of Professor Paul Wender for receipt of the Tetrahedron Award 2013, 69, 7732-7740.
    [abstract], [pdf]

  1. Wilcock, B. C.; Uno, B. E.; Bromann, G. L.; Clark, M. J.; Anderson, T. M.; Burke, M. D. "Electronic tuning of site-selectivity" Nature Chemistry 2012, 4, 996-1003.
    [abstract], [pdf], [supp info]

  1. K.C. Gray, D.S. Palacios, I. Dailey, M.M. Endo, B.E. Uno, B.C. Wilcock, M.D. Burke. "Amphotericin primarily kills yeast by simply binding ergosterol" Proceedings of the National Academy of Sciences U.S.A. 2012, 109, 2234-2239.
    [abstract], [pdf], [supp info]

  1. G.R. Dick, E.M. Woerly, M.D. Burke. "A General Solution for the 2-Pyridyl Problem" Angewandte Chemie International Edition 2012, 51, 2667-2672 .
    [abstract], [pdf], [supp info]

  1. J. Li, M.D. Burke. "Pinene-Derived Iminodiacetic Acid (PIDA): A Powerful Ligand for Stereoselective Synthesis and Iterative Cross-Coupling of C(sp3) Boronate Building Blocks" Journal of the American Chemical Society 2011, 133, 13774-13777.
    [abstract], [pdf], [supp info]

  1. S. Fujii, S.Y. Chang, M.D. Burke. "Total Synthesis of Synechoxanthin through Iterative Cross-Coupling" Angewandte Chemie International Edition 2011, 50, 7862-7864.
    [abstract], [pdf], [supp info]

  • Highlighted on the cover of Angew. Chem. August, 16 2011; Volume 50, Issue 34.
  • Highlighted in Chemistry World.
  • Highlighted in Illinois News.
  1. D.S. Palacios, I. Dailey, D.M. Siebert, B.C. Wilcock, M.D. Burke. "Synthesis-enabled functional group deletions reveal key underpinnings of amphotericin B ion channel and antifungal activities" Proceedings of the National Academy of Sciences U.S.A. 2011, 108, 6733-6738.
    [abstract], [pdf], [supp info]

    Publication 22
  1. E.M. Woerly, J.R. Struble, N. Palyam, S.P. O'Hara, M.D. Burke. "(Z)-(2-Bromovinyl)-MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis" Tetrahedron: Special Issue in honor of Professor Dean Toste for receipt of the Tetrahedron Young Investigator Award 2011, 67, 4333-4343.
    [abstract], [pdf]
Publication 21
  1. S.J. Lee, T.M. Anderson, M.D. Burke. "A Simple and General Platform for Generating Stereochemically Complex Polyene Frameworks by Iterative Cross-Coupling" Angewandte Chemie International Edition 2010, 49, 8860-8863.
    [abstract], [pdf], [supp info]
Publication 19
  1. E.M. Woerly, A.H. Cherney, E.K. Davis, M.D. Burke. "Stereoretentive Suzuki-Miyaura Coupling of Haloallenes Enables Fully Stereocontrolled Access to (-)-Peridinin" Journal of the American Chemical Society 2010, 132, 6941-6943.
    [abstract], [pdf], [supp info]

    Publication 18
  1. G.R. Dick, D.M. Knapp, E.P. Gillis, M.D. Burke. "General Method for Synthesis of 2-Heterocyclic N-Methyliminodiacetic Acid Boronates" Organic Letters 2010, 12, 2314-2317.
    [abstract], [pdf], [supp info]
Publication 17
  1. J.R. Struble, S.J. Lee, M.D. Burke. "Ethynyl MIDA boronate: a readily accessible and highly versatile building block for small molecule synthesis." Tetrahedron: Special Issue in honor of Professor Brian Stoltz for receipt of the Tetrahedron Young Investigator Award, 2010, 66, 4710-4718.
    [abstract] , [pdf]
Publication 16
  1. I.A. Dailey, M.D. Burke. "N-(Carboxymethyl)-N-methyl-glycine." Encyclopedia of Reagents for Organic Synthesis, 2010.
    [abstract] , [pdf]
  1. S.G. Ballmer, E.P. Gillis, M.D. Burke. "B-Protected Haloboronic Acids for Iterative Cross-Coupling" Organic Syntheses 2009, 86, 344-359.
    [pdf]
Publication 15
  1. E.P. Gillis, M.D. Burke. "Iterative Cross-Coupling with MIDA Boronates: Towards a General Strategy for Small Molecule Synthesis," Aldrichimica Acta, 2009, 42, 17-27.
    [pdf]
Publication 14
  1. D.M. Knapp, E.P. Gillis, M.D. Burke. "A General Solution for Unstable Boronic Acids: Slow-Release Cross-Coupling from Air-Stable MIDA Boronates." Journal of the American Chemical Society 2009, 131, 6961-6963.
    [abstract], [pdf], [supp info]

    Publication 13
  • Highlighted in Chemical and Engineering News.
  • One of the top 10 "Most Read" articles in Journal of the American Chemical Society, May-June 2009
  • Highlighted in Angewandte Chemie International Edition
  • For Prof. Richard Taylor's application of this methodology in the total synthesis of dictyosphaeric acid A, see Angewandte Chemie International Edition 2010, 49, 5574-5577.
  • For Prof. Jon Ellman's recent development of asymmetric additions to aldimines via slow-release with MIDA boronates, see The Journal of Organic Chemistry 2010, 75, 3147-3150.
  • For an application of this latter methodology to the total synthesis of aurantioclavine, see Organic Letters 2010, 12, 2004-2007.
  1. B.E. Uno, E.P. Gillis, M.D. Burke. "Vinyl MIDA Boronate: a readily accessible and highly versatile building block for small molecule synthesis" Tetrahedron: Special Issue dedicated to Professor Justin Dubois' receipt of the 2008 Tetrahedron Young Investigator Award, Tetrahedron 2009, 65, 3130-3138.
    [abstract], [pdf]
Publication 11
  1. E.P. Gillis, M.D. Burke. "Multistep Synthesis of Complex Boronic Acids from Simple MIDA Boronates" Journal of the American Chemical Society 2008, 130, 14084-14085.
    [abstract], [pdf], [supp info]

    Publication 10
  1. S.J. Lee, K.C. Gray, J.S. Paek, M.D. Burke. "Simple, Efficient, and Modular Syntheses of Polyene Natural Products via Iterative Cross-Coupling" Journal of the American Chemical Society 2008, 130, 466-468. [abstract], [pdf], [supp info]

    Publication 9
  • Highlighted in Angewandte Chemie International Edition "Controlled Iterative Cross-Coupling: On the Way to the Automation of Organic Synthesis" 2009, 48,5240-5244.
  • Highlighted in Angewandte Chemie International Edition Devising boron reagents for orthogonal functionalization through Suzuki-Miyaura cross-coupling," 2009, 48, 3565-3568
  • Highlighted in the 3 November 2008 issue of Chemistry World
  • Highlighted in the 20 December 2007 issue of Chemistry World
  • Highlighted in Chemistry and Industry
  • Highlighted in SynForm.
  • Reviewed in Accounts of Chemical Research 2008, 41, 1461-1473
  • Included in a new textbook "Organometallics" authored by Professor John Wolfe.
  1. D.S. Palacios, T.M. Anderson, M.D. Burke "A Post-PKS Oxidation of the Amphotericin B Skeleton Predicted to be Critical for Channel Formation is Not Required for Potent Antifungal Activity" Journal of the American Chemical Society 2007, 129, 13804-13805. [abstract], [pdf], [supp info]

    Publication 8
  • Highlighted in the Jan 1, 2008 issue of Nature Chemical Biology.
  • Highlighted in The Scientist
  • Highlighted in Natural Product Reports 2008, 25, 11-15.
  1. E.P. Gillis and M.D. Burke. "A Simple and Modular Strategy for Small Molecule Synthesis: Iterative Suzuki-Miyaura Coupling of B-Protected Haloboronic Acid Building Blocks." Journal of the American Chemical Society 2007, 129, 6716-6717. [abstract], [pdf], [supp info]

    Publication 7
  1. M.D. Burke. "Molecular Prosthetics: Replicating the Functions of the Molecules of Life" Enhancing Chemistry Conference sponsored by the American Chemical Society. University of Illinois at Urbana-Champaign, Urbana, Illinois, March 17, 2006.


  1. M.D. Burke, E.M. Berger, and S.L. Schreiber. "A Synthesis Strategy Yielding Skeletally Diverse Small Molecules Combinatorially." Journal of the American Chemical Society 2004, 126, 14095-14104.
  1. M.D. Burke and S.L. Schreiber. "A Planning Strategy for Diversity-Oriented Synthesis."Angewandte Chemie International Edition 2004, 43, 46-58.

    • This paper has been recognized by Thomson-ISI as "one of the most cited recent papers in the field of chemistry." ISI Essential Science Indicators (> 570 citations).
  1. M.D. Burke, E.M. Berger, and S.L. Schreiber. "Generating Diverse Skeletons of Small Molecules Combinatorially." Science 2003, 302, 613-618.
      This paper was selected as one of the top Chemistry Highlights 2003 "for making natural-product-like libraries of unprecedented diversity." Chemical & Engineering News 2003, 81:51, 48. For additional commentaries see: Chemical & Engineering News 2003, 81:43, 40; Nature Reviews Drug Discovery "Highlights," 2003, 2:12, 948; Chemical & Engineering News 2004, 82:40, 32. This work has also been reviewed in Nature, 2004, 432, 846-854.
  1. R.M. Kohli, M.D. Burke, X.L. Tao, and C.T. Walsh. "Chemoenzymatic Route to Macrocyclic Hybrid Peptide/Polyketide-like Molecules." Journal of the American Chemical Society 2003, 125, 7160-7161.
  1. M.C. White, M.D. Burke, S. Peleg, P. Dolan, T. Kensler, H. Brem, and G.H. Posner. "Conformationally Restricted Hybrid Analogs of 1,25-Dihydroxyvitamin D3, Design, Synthesis, and Preliminary Biological Evaluation." Bioorganic & Medicinal Chemistry 2001, 9, 1691-1699.
  1. G.H. Posner, J.K. Lee, Q. Wang, S. Peleg, M.D. Burke, H. Brem, P. Dolan, and T. Kensler. "Non-Calcemic, Antiproliferative, Transcriptionally-Active, 24-Fluorinated Hybrid Analogs of the Hormone 1a,25-Dihydroxyvitamin D3. Synthesis and Preliminary Biological Evaluation." Journal of Medicinal Chemistry 1998, 41, 3008-3014.