Research Overview

The research in this group is primarily involved with the invention of new synthetic reactions and the origin of stereocontrol in fundamental carbon-carbon bond forming reactions. The long-standing emphasis in our laboratories centers on the relationship between structure, reactivity and stereoselectivity in a variety of organo-element systems such as: palladium-catalyzed, cross-coupling reactions with organofunctional silicon compounds, asymmetric catalysis of carbonyl addition reactions, and applying the reducing power of the Water-Gas Shift Reaction to organic synthesis. We have pioneered the concept of chiral Lewis base activation of Lewis acids for catalysis of electrophilic reactions in the Main Group for elements in Groups 14, 16 and 17. In addition, our research program encompasses the development and application of tandem nitroalkene cycloadditions for the synthesis of complex natural (alkaloids) and unnatural (fenestranes) nitrogen containing compounds. In recent years, we have been focused on the amalgamation of diversity-oriented synthesis with chemoinformatic analysis for the identification and optimization of catalysts for enantioselective reactions using organic and organometallic compounds. We maintain a long-standing interest in the structural chemistry and reactivity of organolithium, -phosphorus and –zinc compounds.

Research Projects