The research in my group is primarily involved with the invention
of new synthetic reactions, on the origin of stereocontrol
in fundamental carbon-carbon and carbon-heteroatom bond forming
reactions, and in the application of these developments to
the synthesis of complex molecular structures. A continuing
theme of the work in these laboratories is the relationship
between structure, reactivity and stereoselectivity in a variety
of organo-element systems, particularly, silicon, phosphorus,
tin, sulfur and lithium compounds. In recent years this interest
has focused on palladium catalyzed cross-coupling reactions
with organofunctional silicon compounds, asymmetric catalysis
of carbonyl addition reactions and chiral Lewis base activation
of Lewis acids. In addition my research program encompasses
the development and application of tandem heterodiene cycloadditions
for the synthesis of complex natural (alkaloids) and unnatural
(fenestranes) nitrogen containing compounds. My group maintains
a long standing interest in enantioselective cyclopropanation
with organozinc reagents, and other asymmetric reactions of
organometallic reagents.
RESEARCH PROJECTS
Lewis Base Activation of Lewis Acids
Palladium-Catalyzed Cross-Coupling
of Organosilicon Compounds
Tandem Cycloaddition Chemistry of
Nitroalkenes
|
