Laboratory for
Biomaterials and Tissue Engineering
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Resarch Overview
We focus on biomaterials for tissue engineering applications. Our approach to tissue engineering brings together cells with biocompatible materials and chemical cues to improve tissue regeneration. We engineer materials by controlling their mechanical properties such as stiffness, toughness, and degradability. These materials are combined with both soluble and insoluble chemical factors such as cell adhesion domains and growth factors. Ultimately, the engineered biomaterials are able to deliver chemical cues with the appropriate temporal and concentration distributions to elicit our desired cell response. Through this research, we will establish innovative strategies for in vitro cell culture and in vivo cell transplantation for use in tissue engineering and cell-based therapies.
recent Publications
Jeong, J., Cha, C., Kaczamarowki, A., Oh, S., Kong, H.J. "Polyaspartamide Micelle-to-Vesicle Transition Driven by Metallic Nanoparticles." Soft Matter, In press (2012).
V. Chan, J.H. Jeong, P. Bajaj, M. Collens, T. Saif, H.J. Kong, R. Bashir "Multi-Material Bio-Fabrication of Hydrogel Cantilevers and Actuators with Stereolithography. " Lab on a Chip 12, 88 (2012).
J. H. Jeong, V. Chan, C. Cha, P. Zortuluna, C. Dyck, K. Jimmy Hsia, R. Bashir, H. J. Kong "Living' Microvascular Stamp for Patterning of Functional Neovessels; Orchestrated Control of Matrix Property and Geometry," Advanced Materials (2011).
C. Cha, J.H. Jeong, X. Tang, A. Zill, S.C. Zimmerman, Y. Prakash, T. Saif, H.J. Kong, "Top-down synthesis of versatile polyaspartamide linkers for single-step protein conjugation to materials," Bioconjugate Chemistry (2011).
Y. Liang*, J.H. Jeong*, R. DeVolder, C. Cha, F. Wang, Y. Tong, H.J. Kong, "A Cell-instructive hydrogel to regulate malignancy of 3D tumor spheroids with matrix rigidity," Biomaterials, 32, 9308 (2011) [* Equal Contribution].
C. Cha, S.R. Kim, Y.S. Jin, H.J. Kong , "Tuning structural durability of yeast-encapsulating alginate gel beads with interpenetrating networks for sustained bioethanol production," Biotechnology & Bioengineering 109, 63 (2012).
J. Schmidt, J.H. Jeong, H.J. Kong , "Interplay of cell adhesion cues and curvature of a cell adherent alginate microgel for multipotent stem cell culture," Tissue Engineering 17, 2687 (2011).
C. Cha, J.H. Jeong, J. Shim, H.J. Kong , "Tuning the dependency between stiffness and permeability of cell-encapsulating hydrogel with hydrophilic pendant chains," Acta Biomaterialia 7, 3719 (2011).
R. DeVolder, H. Bae, J. Lee, H.J. Kong, "Directed blood vessel growth using angiogenic microfiber/microparticle composite patch," Advanced Materials 23, 3139 (2011).
P. Zorulutuna, J.H. Jeong, H.J. Kong, R. Bashir, "Stereolithography-based hydrogel microenvironments for examining cellular interactions," Advanced Functional Materials 21, 3642 (2011) [Cover Article].
C. Cha, E.S. Kim, I.W. Kim, H.J. Kong, "Integrative design of a Poly(Ethylene Glycol)-Poly(Propylene Glycol)-Alginate hydrogel to control three dimensional biomineralization," Biomaterials 32, 2695 (2011).
Y. Liang, T.W. Jensen, E.J. Roy, C. Cha, R.J. DeVolder, R.E. Kohman, B.Z. Zhang, K.B. Textor, L.A. Rund, L.B. Schook, Y.W. Tong, H.J. Kong, "Tuning the non-equilibrium state of a drug-encaspulated poly(ethylene glycol) hydrogel for stem and progenitor cell mobilization," Biomaterials, 32, 2004 (2011).
news
Dr. Kong has been appointed as a fellow of UIUC's Center for Advanced Study in 2012-2013 .
John Schmidt has successfully defended his Ph.D. defense. Congratulations! (Jan. 2012) .
Cathy Chu has successfully defended his Ph.D. defense. Congratulations! (Dec. 2011) .
Chaenyung Cha has successfully defended his Ph.D. defense. Congratulations! (Nov. 2011) .
Dr. Kong received an NIH R01 research grant for research in theranostic multifunctional nanoparticle. This research will be conducted in collaboration with Dr. Steven Zimmerman (Chemistry, University of Illinois) and Dr. Sanjay Misra (Mayo Clinic). (Sep. 2011). .
Prof. Kong has been awarded the prestigious Young Investigator Award 2011 from the Korean Institute for Chemical Engineers.
Cathy has been named a Drickamer Fellow in the Department of Chemical and Biomolecular Engineering for 2010-2011.
Chaenyung has been named a Drickamer Fellow in the Department of Chemistry for 2010-2011.
Johana has been awarded the prestigious NSF graduate fellowship.
Jae Hyun was awarded honorable mention at UIC's Stem Cell and Regenerative Medicine Symposium (March 24, 2010).
Dr. Kong received the prestigious NSF career award for research and educational efforts to design biomaterials with an in-depth understanding of biology.
Last Updated: 12/29/2011 |
