Laboratory for
Biomaterials and Tissue Engineering
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Resarch Overview
Our group's research goals are to develop advanced biomaterials that will support diagnosis, repair or regeneration of blood vessels for treatments of cardiovascular diseases, wounds and tissue defects. To accomplish these goals, we are currently focusing on developing two different biomaterial design strategies; (1) Decoupling dependency between rigidity, permeability, and degradation rate of a drug or cell-encapsulating hydrogel and (2) Self-assembly of theranostic polymersomes enabling targeting, tracking, and treatment. Furthermore, we are using the resulting biomaterials: (3) to better understand the role of extracellular microenvironments on regulating cellular activities involved in neovascularization, (4) to control growth direction and spacing of functional microvascular networks at physiologically relevant sub-micrometer length scale, and (5) to image and repair blood vessels damaged by pro-inflammation.
recent Publications
Jeong, J.H., Liang, Y., Jang, M., Cha, C., Chu, C., Lee, H., Jung, W.G., Kim, J.W., Boppart, S.A., & Kong, H.J. " Stiffness-modulated water retention and neovascularization of dermal fibroblast-encapsulating collagen gel." Tissue Engineering (In press, 2013).
Schmidt, J., Jeong, J.H., Chan, V., Cha, C., Baek, K., Lai, M-H, Bashir, R., Kong, H.J. Tailoring the Dependency between Rigidity and Water Uptake of a Microfabricated Hydrogel with the Conformational Rigidity of a Polymer Cross-linker. Biomacromolecules (In press, 2013).
Jeong JH, Schmidt JJ, Kohman RE, Zill AT, Devolder RJ, Smith CE, Lai MH, Shkumatov A, Jensen TW, Schook LG, Zimmerman SC, Kong H.J. Leukocyte-Mimicking Stem Cell Delivery via in Situ Coating of Cells with a Bioactive Hyperbranched Polyglycerol. Journal of the American Chemical Society (In press, 2013).
news
Jinrong Chen became a M-CNTC fellow (May 2013) Congratulations!
Jaehyun's paper in Journal of the American Chemical Society was highlighted by C&EN news .
Eleni Antoniadou has been named 2013 Woman of the Year in Science and Technology for the UK at the 2013 FDM Everywoman In Technology Awards. Congratulations!
Dec. 7. 2012, Ross J. Devolder successfully defended his Ph.D. defense. Congratulations!
Dr. Kong has been has been named a recipient of the 2012 Engineering Dean's Award for Excellence in Research.
Dr. Kong has been appointed as a fellow of UIUC's Center for Advanced Study in 2012-2013 .
Nick Clay became a M-CNTC fellow (Sep. 2012) Congratulations! .
Cartney Smith became a NIH-CBI trainee (Sep. 2012) .
Last Updated: 03/17/2012 |
