- Synthesis and Fabrication of Smart Hydrogels: Differential controls of chemical, mechanical and transport properties of smart, bioactive hydrogels for drug delivery, 3D cell culture, cell transplantation, and anti-fouling.
- Modular Assembly of Multifunctional Nano- & Microparticles: Modular assembly of multifunctional nano- and microparticles for diagnosis, imaging, and treatments of cardiovascular diseases.
- Directing Stem Cell Transports: Development of nanomaterials for targeted delivery and in situ regulation of therapeutic stem cells.
- Cell and Tissue Engineering: Engineering of cell clusters and tissue for understanding emergent cell behavior towards tissue development and pathogenesis and assembling “living” biological machinery.
(a) Effects of poly(ethylene glycol)diacrylate (PEGDA) molecular weight hydrogel self-folding (a-1 and a-2). (b) Magnetic resonance image of self-folded, multi-walled PEGDA hydrogel.
In situ self-folding of a PEGDA hydrogel at an implantation site
Baek et al., Adv. Mat. (2013)
Microvascular Stamp for Patterning of Functional Neovessels
Images of patterned vasculature formed under microstamp implants
Jeong et al., Adv. Mat. (2012)
Proangiogenic fiber/microparticle patch assembled through in situ electrospinning and electrospraying
DeVolder et al., Adv. Mat. (2011)
Gadolinium-Coated Liposomes for Vascular Imaging
(Left) Scheme of liposome particles coated with gadolinium using a chitosan fastener; (Right) MR images of two animal models with injection of Gd-coated liposomes.
Smith et al., ACS Nano (2013)
Ellipsoidal Polymersomes for Highly Efficient Cell Targeting
Polyaspartamide polymer with a hydrophobic chain can self-assemable into an ellipsoidal naonparticle. This special shape enables efficient adhesion to stem cells.
Lai et al., Adv. Funct. Mater. (2012)
Chemical Modification of Stem Cell Surface to Induce Adhesion
(Left) A highly-branched polymer can be easily attached to the surface of a stem cell; (Right) With the polymer attached, bioadhesion kinetics are improved.
Jeong et al., JACS (2013)
(Left) Scheme of soft/stiff cell-instructive collagen gels; (Right) Cancer malignancy in collagen gels with different cues.
Liang & Jeong et al., Biomaterials (2011)