BioInterfaces and Cell Mechanics Laboratory
The Biointerfaces subgroup is investigating how molecular and surface forces affect biomolecular adhesion and protein adsorption at interfaces. Projects address biomaterial surface design, drug delivery coatings, sensor surface coatings, antifouling coatings, smart materials, and biomolecular recognition. We use molecular force probes, soft lithography and surface analytical tools to address these issues.
The Mechano-Biology subgroup investigates mechano-transduction in cells and tissues, in the context of tissue function and disease. This multi-scale, multi-disciplinary effort bridges protein biophysics, cell mechanics, and tissue engineering, to establish how mechanical cues instruct cell behavior in both mature tissues and in human disease. Current projects focus on ventilator induced lung injury, cardiovascular disease, and aging. This work is in collaboration with clinicians and tissue engineers.
The Cell and Molecular Biophysics subgroup investigates how proteins transduce mechanical and biochemical signals across cell membranes to alter intracellular signaling and cell adhesion. Biophysical approaches include atomistic simulations, single molecule force measurements, fluorescent protein biosensors, and quantitative measurements of intercellular adhesion kinetics.

Undergraduate research projects available

  • Invesigations of nano particle interactions with model biological membranes (with C. Murphy)
  • LabView programming to analyze interfacial properties of biomaterials at the nanoscale.
  • Protein adsorption on biomaterials. Surface analytical methods and surface chemistry are used to study protein adsorption and function on biomaterials.
  • Protein engineering. Design and express protein constructs used to investigate how different biochemical cues affect cell function in engineered biomaterials (with Kong)
  • Protein engineering. Design and express protein constructs used to investigate how proteins accumulate when cells interact, and assess the force developed due to protein interactions, using Super resolution microscopy (with TJ Ha)

Contact Dr. Jun Wu: Please include in your email a resume with your education background (major, GPA etc.), major courses taken and previous research experience etc.

Group News

Congratulations to our stars!

Sam Barrick received a 2014 Drickamer graduate fellowship.

Zanab Rahil was awarded a 2yr Cancer Nanotechnology CNST fellowship.

Arkaprava Dan received a 2014 Ullyot graduate fellowship.

Jun Wu received the 2015 Shen postdoctoral fellowship.

Meredith Kisting received an American Heart Association summer undergraduate research fellowship for 2014.

Arkaprava Dan received a 2014 Widiger Summer Research Fellowship. Congratulations Arka!


Page last modified on July 27, 2015, at 05:12 PM