BioInterfaces and Cell Mechanics Laboratory

The BioInterfaces and Cellular Mechanics Laboratory is establishing fundamental mechanisms by which mechanical signals conveyed through biomacromolecules across cell membranes impact cell and tissue function, disease, and developmental biology. Topics span time and length scales from atoms to the clinic.

The cell and molecular biophysics group investigates the biophysical mechanisms by which proteins transduce mechanical and biochemical signals bidirectionally across cell membranes to alter intracellular signaling or cell adhesion. Approaches include atomistic simulations, single molecule measurements, fluorescent protein biosensors, and biochemical tools.
The mechano-biology group is investigating mechano-transduction mechanisms in cells and tissues. This multi-scale, multi-disciplinary effort bridges protein biophysics, cell mechanics, and tissue engineering, to establish how force-activated signaling mechanisms instruct cell behavior. Collaborations with clinicians and tissue engineers are determining how mechanical forces and genetic variations contribute to cardiovascular disease and tissue differentiation.
The biointerfaces group studies fundamental molecular forces and their central roles in promoting or preventing cell adhesion. We address relationships between interfacial chemistry, intermolecular and surface forces, and how those forces ultimately affect biological adhesion.

Undergraduate positions available

  • Study nano particle interactions with model biological membranes
  • MatLab programming for analyses of cell biomechanics measurements
  • Protein adsorption on different materials
  • Protein engineering

Contact Dr. Jun Wu:

Group News

Congratulations to our stars!

Sam Barrick received a 2014 Drickamer graduate fellowship.

Zanab Rahil was awarded an IGERT fellowship.

Arkaprava Dan received a 2014 Ullyot graduate fellowship.

Jun Wu received the 2015 Shen postdoctoral fellowship.

Meredith Kisting received an American Heart Association summer undergraduate research fellowship for 2014.

Arkaprava Dan received a 2014 Widiger Summer Research Fellowship. Congratulations Arka!


Page last modified on August 28, 2014, at 11:07 AM