Research.AtomicForceMicroscopy History

Hide minor edits - Show changes to output

August 15, 2010, at 11:10 AM by 76.191.16.15 -
Changed line 6 from:
Force spectroscoy measurements are used to investigate structure/function relationships in adhesion proteins.  Projects include studies of structural determinants of bond strengths, physical chemical basis of binding specificity, and the allosteric regulation of binding in multidomain adhesion proteins. We complement these single molecule investigations with molecular dynamics simulations, which identify critical amino acids in adhesion and binding selectivity. Measurements of single proteins on cell surfaces further determine how the membrane context, inside out signaling, and connections to the cytoskeleton regulate cell adhesion.
to:
Force spectroscoy measurements are used to investigate structure/function relationships of cell surface adhesion proteins.  Projects include studies of structural determinants of bond strengths, physical chemical basis of binding recognition, and allosteric regulation of binding in multidomain adhesion proteins. We complement these single molecule investigations with molecular dynamics simulations, to identify critical amino acids in adhesion and binding selectivity. Measurements of single proteins on cell surfaces further determine how the membrane context, inside out signaling, and connections to the cytoskeleton regulate cell adhesion.
August 15, 2010, at 11:08 AM by 76.191.16.15 -
Deleted lines 3-4:
Contacts: [[mailto:qshi@uiuc.edu|Quanming]], [[mailto:marutham@uiuc.edu|Venkat]]
Changed lines 6-8 from:
Force spectroscoy measurements are used to investigate structure/function relationships in adhesion proteins.  Projects include studies of structural determinants of bond strengths, physical chemical basis of binding specificity, and the allosteric regulation of binding in multidomain adhesion proteins.

We
complement these single molecule investigations with molecular dynamics simulations, which identify critical amino acids in adhesion and binding selectivity. We further demonstrate the biological relevance of our single molecule studies by using these results to predict recognition and adhesion between live cells.
to:
Force spectroscoy measurements are used to investigate structure/function relationships in adhesion proteins.  Projects include studies of structural determinants of bond strengths, physical chemical basis of binding specificity, and the allosteric regulation of binding in multidomain adhesion proteins. We complement these single molecule investigations with molecular dynamics simulations, which identify critical amino acids in adhesion and binding selectivity. Measurements of single proteins on cell surfaces further determine how the membrane context, inside out signaling, and connections to the cytoskeleton regulate cell adhesion. 

 

Page last modified on August 15, 2010, at 11:10 AM