Research.MicroChannels History

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December 25, 2009, at 03:19 PM by 64.198.214.244 -
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One NIH sponsored program is addressing mechanisms underlying metastasis and invasion in cancer.  These cell processes are controlled by the interplay between cell-cell adhesion, which maintains tissue integrity, and cell migration triggered by growth factors or chemokines.  In collaboration with with Fei Wang (http://www.life.illinois.edu/feiwang/) and Ralph Nuzzo (http://augustus.scs.uiuc.edu/nuzzogroup/), we use controlled concentration profiles of growth factors and adhesion proteins to define the biochemistry controlling cross-talk between cell adhesion and chemokine triggered cell migration. In conjunction with engineered cell environments, high resolution live cell imaging visualizes in real time how controlled signals trigger spatiotemporal changes in intracellular proteins underlying cell responses to these signals.  A broad objective of these studies is to identify molecular mechanisms of disease and potential therapeutic targets for drug treatments.
to:
One NIH sponsored program is addressing mechanisms underlying metastasis and invasion in cancer.  These cell processes are controlled by the interplay between cell-cell adhesion, which maintains tissue integrity, and cell migration triggered by growth factors or chemokines.  In collaboration with with Fei Wang (http://www.life.illinois.edu/feiwang/) and Ralph Nuzzo (http://augustus.scs.uiuc.edu/nuzzogroup/), we use controlled concentration profiles of growth factors and adhesion proteins to define the biochemistry controlling cross-talk between cell adhesion and chemokine triggered cell migration. In conjunction with engineered cell environments, high resolution live cell imaging visualizes in real time how signals trigger the spatiotemporal changes in intracellular proteins underlying cell responses.  A broad objective is to identify molecular mechanisms of disease and potential therapeutic targets for drug treatments.
December 25, 2009, at 03:18 PM by 64.198.214.244 -
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Microfabrication and microfluidic devices are being used to study the interplay between complex signaling pathways that control intercellular adhesion and migration.  Quantitative interactions between biochemical systems are difficult to address in vivo, but engineered microenvironments and quantitatively controlled chemical cues enable quantitatively assessments of the interplay between different cell receptors and related signaling pathways controls that control complex cell functions.
to:
Microfabrication and microfluidic devices are being used to study the interplay between complex signaling pathways that control intercellular adhesion and migration.  Quantitative interactions between biochemical systems are difficult to address in vivo. However engineered microenvironments enable the quantitative, spatio-temporal control of chemical cues. With these powerful tools, we are quantitatively assessing  the interplay between different cell receptors and their related signaling pathways controls underlying complex cell functions.
December 25, 2009, at 03:15 PM by 64.198.214.244 -
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We use microfabrication and microfluidic devices to study the interplay between complex signaling pathways that control a range of cell functions.  Quantitative interactions between biochemical systems are difficult to address in vivo, but engineered microenvironments and quantitatively controlled chemical cues enable us to evaluate quantitatively how cross-talk between different chemical pathways controls complex cell functions.
to:
Microfabrication and microfluidic devices are being used to study the interplay between complex signaling pathways that control intercellular adhesion and migration.  Quantitative interactions between biochemical systems are difficult to address in vivo, but engineered microenvironments and quantitatively controlled chemical cues enable quantitatively assessments of the interplay between different cell receptors and related signaling pathways controls that control complex cell functions.
December 25, 2009, at 03:13 PM by 64.198.214.244 -
Changed line 9 from:
One NIH sponsored program is addressing mechanisms underlying metastasis and invasion in cancer.  These cell processes are controlled by the interplay between cell-cell adhesion, which maintains tissue integrity, and cell migration triggered by growth factors or chemokines.  In collaboration with with Fei Wang (http://www.life.illinois.edu/feiwang/) and Ralph Nuzzo (http://augustus.scs.uiuc.edu/nuzzogroup/), we use controlled concentration profiles of growth factors and adhesion proteins to define the biochemistry controlling cross-talk between cell adhesion and chemokine triggered cell migration. In conjunction with engineered cell environments, high resolution live cell imaging visualizes in real time how controlled signals trigger spatiotemporal changes in intracellular proteins underlying cell responses to these signals.  A broad objective of these studies is to identify molecular mechanisms of disease and potential therapeutic targets.
to:
One NIH sponsored program is addressing mechanisms underlying metastasis and invasion in cancer.  These cell processes are controlled by the interplay between cell-cell adhesion, which maintains tissue integrity, and cell migration triggered by growth factors or chemokines.  In collaboration with with Fei Wang (http://www.life.illinois.edu/feiwang/) and Ralph Nuzzo (http://augustus.scs.uiuc.edu/nuzzogroup/), we use controlled concentration profiles of growth factors and adhesion proteins to define the biochemistry controlling cross-talk between cell adhesion and chemokine triggered cell migration. In conjunction with engineered cell environments, high resolution live cell imaging visualizes in real time how controlled signals trigger spatiotemporal changes in intracellular proteins underlying cell responses to these signals.  A broad objective of these studies is to identify molecular mechanisms of disease and potential therapeutic targets for drug treatments.
December 25, 2009, at 03:12 PM by 64.198.214.244 -
Changed line 9 from:
One NIH sponsored program is addressing mechanisms underlying metastasis and invasion in cancer.  These cell processes are controlled by the interplay between cell-cell adhesion, which maintains tissue integrity, and cell migration triggered by growth factors or chemokines.  We are collaborating with Fei Wang (http://www.life.illinois.edu/feiwang/) and Ralph Nuzzo (http://augustus.scs.uiuc.edu/nuzzogroup/).  We use controlled concentration profiles of growth factors and adhesion proteins to define the biochemistry controlling cross-talk between cell adhesion in tissues and chemokine triggered cell migration. In conjunction with engineered cell environments, high resolution live cell imaging visualizes in real time how controlled signals trigger spatiotemporal changes in intracellular proteins that may regulate tumor metastasis.  The broad objective of this systems level approach is to identify drug targets for the prevention and treatment of disease.
to:
One NIH sponsored program is addressing mechanisms underlying metastasis and invasion in cancer.  These cell processes are controlled by the interplay between cell-cell adhesion, which maintains tissue integrity, and cell migration triggered by growth factors or chemokines.  In collaboration with with Fei Wang (http://www.life.illinois.edu/feiwang/) and Ralph Nuzzo (http://augustus.scs.uiuc.edu/nuzzogroup/), we use controlled concentration profiles of growth factors and adhesion proteins to define the biochemistry controlling cross-talk between cell adhesion and chemokine triggered cell migration. In conjunction with engineered cell environments, high resolution live cell imaging visualizes in real time how controlled signals trigger spatiotemporal changes in intracellular proteins underlying cell responses to these signals.  A broad objective of these studies is to identify molecular mechanisms of disease and potential therapeutic targets.

Page last modified on December 25, 2009, at 03:19 PM