Research in the BioInterfaces and Cell Mechanics Group focuses on understanding cell communication with the environment. A major current emphasis is on mechanisms by which cells sense and transduce chemical and mechanical information to regulate cell functions. We use multiscale approaches to address this. Atomistic simulations and single molecule experimental methods determine relationships between molecular structure and the mechanical properties of protein bonds. Measurements at the single cell level establish links between molecular properties and the dynamics and strength of cell adhesion. A major new focus in the group is on determinations of how cells sense the mechanical environment through cell surface adhesion proteins, and the interplay between biomaterials design, mechanics, and cell functions.