Research.SurfaceForceApparatus History

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December 25, 2009, at 03:29 PM by 64.198.214.244 -
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We use the SFA to measure the forces between cell surface proteins, in order to identify relationships between structure, molecular recognition, and biological adhesion. Current research is exploring recognition and adhesion between cell surface adhesion proteins. A major focus is on the intercellular adhesion proteins cadherins. In other recent investigations of molecular recognition in immunity, we used this approach to identify how the folded structures of multivalent receptors contribute to the recognition of pathogens such as HIV or contribute to susceptibility or resistance to viral infections.
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We use the SFA to measure the forces between cell surface proteins, in order to identify relationships between structure, molecular recognition, and biological adhesion. A major focus is on the intercellular adhesion proteins cadherins. In other recent investigations of molecular recognition in immunity, we used this approach to identify how the folded structures of multivalent receptors contribute to the recognition of pathogens such as HIV or contribute to susceptibility or resistance to viral infections.
December 25, 2009, at 03:28 PM by 64.198.214.244 -
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In one research area, we use the SFA to measure the forces between cell surface proteins, to identify relationships between structure, molecular recognition, and biological adhesion. Current research is exploring recognition and adhesion between cell surface adhesion proteins.  A major focus is on the intercellular adhesion proteins cadherins. Other recent work identified how protein folding and the organization of multivalent ligand binding sites in immune proteins impact pathogen (HIV) recognition and susceptibility to viral infections.
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We use the SFA to measure the forces between cell surface proteins, in order to identify relationships between structure, molecular recognition, and biological adhesion. Current research is exploring recognition and adhesion between cell surface adhesion proteins.  A major focus is on the intercellular adhesion proteins cadherins. In other recent investigations of molecular recognition in immunity, we used this approach to identify how the folded structures of multivalent receptors contribute to the recognition of pathogens such as HIV or contribute to susceptibility or resistance to viral infections.
December 25, 2009, at 03:04 PM by 64.198.214.244 -
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Contact: [[mailto:cyxue@illinois.edu|Changying]], [[mailto:mlanger@uiuc.edu |Matt]]
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Contact: [[mailto:cyxue@illinois.edu|Changying]]

Page last modified on December 25, 2009, at 03:29 PM