The research in the Shen lab interfaces between state of art ultra-high resolution nano-electroanalytical chemistry and neurobiology. The main theme of Shen research program is to interrogate chemical, spatial and temporal heterogeneity in biomaterials using chemically-specific nanosensor probes in situ. Currently our efforts are geared towards detecting neurotransmitter release and uptake in/near the synaptic cleft for both electrochemical active and non-active neurotransmitters.