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CHEM 590C, Fall 2011
Welcome to the website for CHEM 590C, Fall 2011 Introduction to Chemical Biology
CHEM 590C has concluded for the semester. The Final Exam was on Saturday, December 10 at 10:00 am through 12:00 noon in 165 NL.
Exams are available for viewing (but NOT pickup) at my office by APPOINTMENT ONLY. ** Final Exam scores and final course grades are now available here (pdf file). ** Your student research project papers were returned at the Final Exam,
along with a grading sheet that included Numerical grades on proposal components — for each component, mean ± sd (n = 30) — 1 = best for all components: Exam 2, out of 100%: mean ± sd = 87 ± 6 (n = 30). Median 88; range 76 to 96. Exam 1, out of 100%: mean ± sd = 74 ± 14 (n = 31). Median 78; range 32 to 94. CHEM 590C Student literature manuscript presentation schedule - student names have been fully updated
Exams No books, papers, notes, or calculators are allowed during any of the exams. Practice Exam 1 - blank - to be taken in one sitting of 1 hour and 20 minutes (not to be turned in) Practice Exam 1 - key - please try the practice exam before looking at its key! Exam 1 - blank - for reference if desired Practice Exam 2 - blank - to be taken in one sitting of 1 hour and 20 minutes (not to be turned in) Practice Exam 2 - key - please try the practice exam before looking at its key! Exam 2 - blank - for reference if desired
Lecture Presentations - please print out on your own all lectures (including Lecture 1) and bring them to the corresponding class meeting Lecture 1 (please print this lecture on your own and bring it to class on Tuesday, August 23; same for all subsequent lectures) - biochemical basics Lecture 2 (for Thursday, August 25) - replication, transcription, translation Handout on energy, equilibrium, and kinetics (No class on Tuesday, August 30) Lecture 3 (for Thursday, September 1) - cell biology basics Lecture 4 (for Tuesday, September 6) - recombinant protein expression and cell culture Lecture 5 (for Thursday, September 8) - analysis of DNA, RNA, protein levels Lecture 6 (for Tuesday, September 13) - model organisms, genetic knockouts, RNAi, and chemical genetics Lecture 7 (for Thursday, September 15) - fluorescence applications Lecture 8 (for Tuesday, September 20) - biomolecular interactions and bioconjugation Lecture 9 (for Thursday, September 22) - combinatorial chemistry Lecture 10 (for Tuesday, September 27) - high-throughput compound screening Midterm Exam 1 - Thursday, September 29 - will cover topics from August 23 through September 20 Lecture 11 (for Tuesday, October 4) - target identification Lecture 12 (for Thursday, October 6) - unnatural amino acid incorporation Lecture 13 (for Tuesday, October 11) - combinatorial biosynthesis Lecture 14 (for Thursday, October 13) - sequence-specific DNA binders Lecture 15 (for Tuesday, October 18) - activity-based protein profiling Lecture 16 (for Thursday, October 20) - molecular basis of cancer Lecture 17 (for Tuesday, October 25) - anti-cancer agents Lecture 18 (for Thursday, October 27) - structure-based design Lecture 19 (for Tuesday, November 1) - stem cells and regenerative medicine Midterm Exam 2 - Thursday, November 3 - will cover topics from August 23 through October 27 Lecture 20 (for Tuesday, November 8) - phase display and yeast hybrid systems Lecture ERR (also for Tuesday, November 8) - error analysis and error bars Lecture 21 (for Thursday, November 10) - ribozymes, riboswitches, and RNA as a drug target ALL LECTURE LINKS ARE NOW ACTIVE Tuesday, November 15: Student project presentations Thursday, November 17: Student project presentations Tuesday, November 29: Student project presentations Thursday, December 1: Student project presentations Tuesday, December 6: Student project presentations Final Exam - Thursday, December 15 - will cover topics from entire course (comprehensive)
Literature Manuscripts for in-class discussions Please print out and critically read EACH of the listed manuscripts IN ADVANCE OF the indicated lecture. Lecture 2 PNAS 1998, 95, 12088 (see also PNAS 1999, 96, 9459) Lecture 3 JACS 2004, 126, 10504 Science 2002, 296, 1459 Science 2002, 296, 1462 Lecture 4 PNAS 2008, 105, 12128 JACS 2006, 128, 4190 Lecture 5 JACS 2004, 126, 3748 JACS 2009, 131, 16392 Lecture 6 Science 2006, 313, 1929 (see recent review ACS Chem. Biol. 2011, 6, 21) Lecture 7 Science 1999, 286, 971 Nat. Chem. Biol. 2010, 6, 667 Lecture 8 Nat. Methods 2005, 2, 99 JACS 2009, 131, 438 Lecture 9 Nature 2004, 430, 873 Nat. Chem. Biol. 2009, 5, 341 Lecture 10 Nature 2002, 416, 653 Nat. Rev. Drug Discov. 2007, 6, 29 Lecture 11 - no in-class literature manuscript discussion Lecture 12 Nature 2010, 464, 1062 Science 2010, 327, 1345 Lecture 13 Nat. Biotechnol. 2006, 24, 1436 Angew. Chem. Int. Ed. 2009, 48, 9658 Lecture 14 Nat. Chem. Biol. 2006, 2, 531 Lecture 15 PNAS 2009, 106, 16598 Lecture 16 PNAS 2007, 104, 1171 JACS 2009, 131, 1658 Lecture 17 Science 2004, 303, 844 Lecture 18 Nature 2005, 435, 677 PNAS 2010, 107, 14903 (see also Science 2009, 326, 1619) Lecture 19 PNAS 2007, 104, 10370 Lecture 20 PNAS 2003, 100, 7632 Lecture ERR J. Cell. Biol. 2007, 177, 7 - to be discussed at Lecture 20 Lecture 21 PNAS 2010, 107, 14321 Lecture 22 Science 2009, 325, 336 (not actually a lecture date; first day of student project presentations) ALL MANUSCRIPT LINKS ARE NOW ACTIVE
Student Research Projects Please note: all papers should be 1.5 line spacing with 1-inch margins and use 12-point Times font. Presentation schedule (presentation dates Nov. 15, Nov. 17, Nov. 29, Dec. 1, and Dec. 6) Guidelines for student projects on personalized medicine Guidelines for student projects on other research topics Suggestions for topics - please be sure to note policy regarding contact and commitment to topic! |
