Publications
reverse chronology
2017 - 2014

2016 -- 2015 -- 2014

2017

Single Cell Neurometabolomics, M. Qi, M.C. Philip, N. Yang, J.V. Sweedler, ACS Chem. Neurosci., 2017, Epub available. DOI:10.1021/acschemneuro.7b00304

Discovery of Leucokinin-like Neuropeptides that Modulate a Specific Parameter of Feeding Motor Programs in the Molluscan Model, Aplysia, G. Zhang, F.S. Vilim, D.-D. Liu, E.V. Romanova, K. Yu, W.-D. Yuan, H. Xiao, A.B. Hummon, T.-T. Chen, V. Alexeeva, S.-Y. Yin, S.-A. Chen, E.C Cropper, J.V. Sweedler, K.R Weiss, J. Jing, J. Biol. Chem., 2017, Epub available. DOI:10.1074/jbc.M117.795450

MALDI MS Guided Liquid Microjunction Extraction for Capillary Electrophoresis–Electrospray Ionization MS Analysis of Single Pancreatic Islet Cells, T.J. Comi, M.A. Makurath, M.C. Philip, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 89, 2017, 7765–7772. DOI:10.1021/acs.analchem.7b01782

Profiling of Microbial Colonies for High-throughput Engineering of Multi-step Enzymatic Reactions via Optically Guided MALDI MS, T. Si, B. Li, T. J. Comi, Y. Wu, P. Hu, Y. Wu, Y. Min, D. A. Mitchell, H. Zhao, J.V. Sweedler, J. Am. Chem. Soc. 139, 2017, 12466–12473. DOI:10.1021/jacs.7b04641

3D-Printed pHEMA Materials for Topographical and Biochemical Modulation of Dorsal Root Ganglion Cell Response, A. Badea, J.M. McCracken, E. Tillmaand, M. Kandel, A. Oraham, M. Mevis, S.S. Rubakhin, G. Popescu, J.V. Sweedler, R. Nuzzo, ACS Appl. Mat. Interfaces 9, 2017, 30318–30328. DOI:10.1021/acsami.7b06742

Microscale Transport Physics  During Atomic Force Microscopy Mass Spectrometry and Improved Sampling Efficiency,  H. Moon, T. J. Comi, S. J. B. Dunham, B. Kwon, J. V. Sweedler, W. P. King, In 2017 19th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), 2017, 24–27. DOI:10.1109/TRANSDUCERS.2017.7993978

Deterministic Integration of Biological and Soft Materials onto 3D Microscale Cellular Frameworks, J. M. McCracken, S. Xu, A. Badea, K.-I. Jang, Z. Yan, D. J. Wetzel, K. Nan, Q. Lin, M. Han, M. A. Anderson, J. W. Lee, Z. Wei, M. Pharr, R. Wang, J. Su, S. S. Rubakhin, J. V. Sweedler, J. A. Rogers, R. G. Nuzzo, Adv. Biosys. 2017, 1700068. DOI:10.1002/adbi.201700068

microMS: A Python Platform for Image-guided Mass Spectrometry Profiling, T.J. Comi, E.K. Neumann, T.D. Do, J.V. Sweedler, J. Am. Soc. Mass Spectrom. 28, 2017, 1919–1928. DOI:10.1007/s13361-017-1704-1

Quantitative Reflection Imaging for Morphology and Dynamics of Live Aplysia Californica Pedal Ganglion Neurons Cultured on Nanostructured Plasmonic Crystals, S. Kang, A. Badea, S.S. Rubakhin, J.V. Sweedler, J. Rogers, R. Nuzzo, Langmuir 33, 2017, 8640–8650. DOI:10.1021/acs.langmuir.6b04454

Dopamine-Modified TiO2 Monolith-Assisted LDI MS Imaging: Development and Application to Simultaneous Localization of Small Metabolites and Large Lipids in Mouse Brain Tissue with High Detection Selectivity and Sensitivity, Q. Wu, J.L. Chu, S.S. Rubakhin, M.U. Gillette, J.V. Sweedler, Chem. Sci. 8, 2017, 3926–3938. DOI:10.1039/C7SC00937B

Single Cell Profiling using Ionic Liquid Matrix-Enhanced Secondary Ion Mass Spectrometry for Neuronal Cell Type Differentiation, T.D. Do, T.J. Comi, S.J.B. Dunham, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 89, 2017, 3078–3086. DOI:10.1021/acs.analchem.6b04819

Categorizing Cells Based on their Chemical Profiles: Progress in Single Cell Mass Spectrometry, T.J. Comi, T.D. Do, S.S. Rubakhin, J.V. Sweedler, J. Am. Chem. Soc. 139, 2017, 3920–3929. DOI:10.1021/jacs.6b12822

A Unique Combination of Micronutrients Rejuvenates Cognitive Performance in Aged Mice, S.D. Perez, K. Du, C. Rendeiro, L. Wang, Q. Wu, S.S. Rubakhin, R. Vazhappilly, J.H. Baxter, J.V. Sweedler, J.S. Rhodes, Behav. Brain Res. 320, 2017, 97–112. DOI:10.1016/j.bbr.2016.11.019

Mass Spectrometry Imaging of Complex Microbial Communities, S.J.B. Dunham, J.F. Ellis, B.Li, J.V. Sweedler, Acc. Chem. Res. 50, 2017, 96–104. DOI:10.1021/acs.accounts.6b00503

Carrot Solution Culture Bioproduction of Uniformly Labeled 13c-Lutein and in Vivo Dosing in Non-Human Primates, J.W. Smith, R.B. Rogers, S. Jeon, S.S. Rubakhin, L. Wang, J.V. Sweedler, M. Neuringer, M.J. Kuchan, J.W. Erdman, Jr., Exp. Biol. Med. (Maywood) 242, 2017, 305–315. DOI: 10.1177/1535370216675067

2016

Single-Cell Analysis at the Threshold, X. Chen, J.C. Love, N.E. Navin, L. Pachter, M.J.T. Stubbington, V. Svensson, J.V. Sweedler, S.A. Teichmann, Nat. Biotech. 34, 2016, 1111–1118. DOI:10.1038/nbt.3721

A D-Amino Acid-Containing Neuropeptide Discovery Funnel, I. Livnat, H-C Tai, E.T. Jansson, L. Bai, E.V. Romanova, T. Chen, K. Yu, S. Chen, Y. Zhang, Z. Wang, D. Liu, K.R. Weiss, J. Jing, J.V. Sweedler, Anal. Chem. 88, 2016, 11868–11876. DOI:10.1021/acs.analchem.6b03658

Label-Free Molecular Imaging of Bacterial Communities of the Opportunistic Pathogen Pseudomonas Aeruginosa, N. Baig, S. Polisetti, N. Morales-Soto, S.J.B. Dunham, J.V. Sweedler, J.D. Shrout, P.W. Bohn, Proc. SPIE 9930, Biosensing and Nanomedicine IX, 2016, 993004–993008. DOI:10.1117/12.2236695

A One-Step Matrix Application Method for MALDI Mass Spectrometry Imaging of Bacterial Colony Biofilms, B. Li, T.J. Comi, T. Si, S.J.B. Dunham, J.V. Sweedler, J. Mass Spectrom. 51, 2016,1030–1035. DOI:10.1002/jms.3827

Identification of Prohormones and Pituitary Neuropeptides in the African cichlid, Astatotilapia burtoni, C. Hu, B.R. Southey, E.V. Romanova, K.P. Maruska, J.V. Sweedler, R.D. Fernald, BMC Genomics 17, 2016, 660. DOI:10.1186/s12864-016-2914-9

Single Cell Peptide Heterogeneity of Rat Islets of Langerhans, E.T. Jansson, T.J. Comi, S.S. Rubakhin, J.V Sweedler, ACS Chem. Biol. 11, 2016, 2588–2595. DOI:10.1021/acschembio.6b00602

On-tissue Derivatization Via Electrospray Deposition for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging of Endogenous Fatty Acids in Rat Brain Tissues, Q. Wu, T.J. Comi, B. Li, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 88, 2016, 5988–5995. DOI:10.1021/acs.analchem.6b01021

Characterization of Bacillus subtilis Colony Biofilms via Mass Spectrometry and Fluorescence Imaging, T. Si, B. Li, K. Zhang, Y. Xu, H. Zhao, J.V. Sweedler, J. Proteome Res. 15, 2016, 1955–1962. DOI:10.1021/acs.jproteome.6b00127

A Neuron-in-Capillary Platform for Facile Collection and Mass Spectrometric Characterization of a Secreted Neuropeptide, C.Y. Lee, Y. Fan, S.S. Rubakhin, S. Yoon, J.V. Sweedler, Sci. Rep. 6, 2016, 26940. DOI:10.1038/srep26940

Mass Spectrometry Imaging and Identification of Peptides Associated with Cephalic Ganglia Regeneration in Schmidtea mediterranea, T-H. Ong, E.V. Romanova, R.H. Roberts-Galbraith, N. Yang, T.A. Zimmerman, J.J. Collins III, J.E. Lee, N.L. Kelleher, P.A. Newmark, J.V. Sweedler, J. Biol. Chem. 291, 2016, 8109–8120. DOI:10.1074/jbc.M115.709196

Metal-assisted Polyatomic SIMS and Laser Desorption/Ionization for Enhanced Small Molecule Imaging of Bacterial Biofilms, S.J.B. Dunham, T.J. Comi, K. Ko, B. Li, N.F. Baig, N. Morales-Soto, J.D. Shrout, P.W. Bohn, and J.V. Sweedler, Biointerphases 11, 2016, 02A325. DOI:10.1116/1.4942884

Aplysia Locomotion: Network and Behavioral Actions of GdFFD, a D-Amino Acid-containing Neuropeptide, C.Y. Yang , K. Yu, Y. Wang, S.A. Chen, D.D. Liu, Z.Y. Wang, Y.N. Su, S.Z. Yang, T.T. Chen, I. Livnat, F.S. Vilim, E.C. Cropper, K.R. Weiss, J.V. Sweedler, J. Jing, PLOS ONE 11, 2016, e0147335. DOI:10.1371/journal.pone.0147335

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2015

Effects of Exercise and Dietary Epigallocatechin Gallate and Beta-Alanine on Skeletal Muscle in Aged Mice, B.D. Pence, T.E. Gibbons, T.K. Bhattacharya, H. Mach, J.M. Ossyra, G. Petr, S.A. Martin, L. Wang, S.S. Rubakhin, J.V. Sweedler, R.H. McCusker, K.W. Kelley, J.S. Rhodes, R.W. Johnson, J.A. Woods, Appl. Physiol. Nutr. Metab., 2015, 1–10. DOI:10.1139/apnm-2015-0372

Analytical Capabilities of Mass Spectrometry Imaging and its Potential Applications in Food Science, B. Li, S.J.B. Dunham, Y. Dong, S. Yoon, M. Zeng, J.V. Sweedler, Trends Food Sci. 47, 2015, 50–63. DOI:10.1016/j.tifs.2015.10.018

Lutein and Brain Function, J.W. Erdman Jr., J.W. Smith, M.J. Kuchan, E.S. Mohn, E.J. Johnson, S.S. Rubakhin, L. Wang,  J.V. Sweedler, M. Neuringer, Foods 4, 547–564. DOI:10.3390/foods4040547

Multimodal Chemical Imaging of Molecular Messengers in Emerging Pseudomonas Aeruginosa Bacterial Communities, N.F. Baig, S.J.B. Dunham, N. Morales-Soto, J.D. Shrout, J.V. Sweedler, P.W. Bohn, Analyst 140, 2015, 6544–6552. DOI:10.1039/c5an01149c

Peptidomics and Secretomics of the Mammalian Peripheral Sensory-Motor System, E.G. Tillmaand, N. Yang, C.A.C. Kindt, E.V. Romanova, S.S. Rubakhin, J.V. Sweedler, J. Am. Soc. Mass Spectrom. 26, 2015, 2051–2061. DOI:10.​1007/​s13361-015-1256-1

Differential Peptidomics Assessment of Strain and Age Differences in Mice in Response to Acute Cocaine Administration, E.V. Romanova, S.S. Rubakhin, J.R. Ossyra, J.A. Zombeck, M.R. Nosek, J.V. Sweedler, J.S. Rhodes, J. Neurochem. 135, 2015, 1038-1048. DOI:10.1111/jnc.13265

Peptidomics for the Discovery and Characterization of Neuropeptides and Hormones, E.V. Romanova and J.V. Sweedler, Trends Pharmacol. Sci. 36, 2015, 579–586. DOI:10.1016/j.tips.2015.05.009

Classification of Large Cellular Populations and Discovery of Rare Cells Using Single Cell Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, T.H. Ong, D.J. Kissick, E.T. Jansson, T.J. Comi, E.V. Romanova, S.S. Rubakhin, J.V. Sweedler, Anal. Chem. 87, 2015, 7039–7042. DOI:10.1021/acs.analchem.5b01557

Microbeam-Coupled Capillary Electrophoresis, G. Garty, M.U. Ehsan, M. Buonanno, Z. Yang, J.V. Sweedler, D.J. Brenner, Radiat. Prot. Dosimet. 166, 2015, 188–191. DOI:10.1093/rpd/ncv148

Rapid Mitogenic Regulation of the Mtorc1 Inhibitor, Deptor, by Phosphatidic Acid, M.S. Yoon, C.L. Rosenberger, C. Wu, N. Truong, J.V. Sweedler, J. Chen, Mol. Cell 58, 2015, 549–556. DOI:10.1016/j.molcel.2015.03.028

Nanopipet-Based Liquid-Liquid Interface Probes for the Electrochemical Detection of Acetylcholine, Tryptamine, and Serotonin Via Ionic Transfer, M.L. Colombo, J.V. Sweedler, M. Shen, Anal. Chem. 87, 2015, 5095–5100. DOI:10.1021/ac504151e

Mass Spectrometry Imaging and GC-MS Profiling of the Mammalian Peripheral Sensory-Motor Circuit, S.S. Rubakhin, A. Ulanov, J.V. Sweedler, J. Am. Soc. Mass Spectrom. 26, 2015, 958–966. DOI:10.1007/s13361-015-1128-8

Mass Spectrometry-based Characterization of Endogenous Peptides and Metabolites in Small Volume Samples, T-H. Ong, E.G. Tillmaand, M. Makurath, S.S. Rubakhin, J.V. Sweedler, Biochim. Biophys. Acta 1854, 2015, 732–740. DOI:10.1016/j.bbapap.2015.01.008

Integration of Untargeted Metabolomics with Transcriptomics Reveals Active Metabolic Pathways, K. Cho, B.S. Evans, B.M. Wood, R. Kumar,  T.J. Erb, B.P. Warlick, J.A. Gerlt, J.V. Sweedler, Metabolomics 11, 2015, 503–517. DOI:10.​1007/​s11306-014-0713-3

TOP

2014

Identification of Best Indicator of Peptide-Spectrum Match Using a Permutation Resampling Approach, M.N. Akhtar, B.R. Southey, P.E. Andrén, J.V. Sweedler, S.L. Rodriguez-Zas, J. Bioinform. Comput. Biol. 12, 2014, 1440001. DOI:10.1142/S0219720014400010

Accurate Assignment of Significance to Neuropeptide Identifications Using Monte Carlo K-Permuted Decoy Databases, M.N. Akhtar, B.R. Southey, P.E. Andrén, J.V. Sweedler, S.L. Rodriguez-Zas, PLoS ONE 9, 2014, e111112. DOI:10.1371/journal.pone.0111112

Correlated Imaging with C60-SIMS and Confocal Raman Microscopy: Visualization of Cell-scale Molecular Distributions in Bacterial Biofilms, E.J. Lanni, R.N. Masyuko, C.M. Driscoll, S.J.B. Dunham, J.D. Shrout, P.W. Bohn, J.V. Sweedler, Anal. Chem. 86, 2014, 10885-10891. DOI:10.1021/ac5030914

Analysis of Endogenous Nucleotides by Single Cell Capillary Electrophoresis-Mass Spectrometry, J-X. Liu, J.T. Aerts, S.S. Rubakhin, X-X. Zhang, J.V. Sweedler, Analyst 139, 2014, 5835–5842. DOI:10.1039/C4AN01133C

Biomolecular Imaging with a C60-SIMS/MALDI Dual Ion Source Hybrid Mass Spectrometer: Instrumentation, Matrix Enhancement, and Single Cell Analysis, E.J. Lanni, S.J.B. Dunham, P. Nemes, S.S. Rubakhin, J.V. Sweedler, J. Amer. Soc. Mass Spectrom. 25, 2014, 1897–1907. DOI:10.1007/s13361-014-0978-9

MALDI-guided SIMS: Multiscale Imaging of Metabolites in Bacterial Biofilms, E.J. Lanni, R.N. Masyuko, C.M. Driscoll, J.T. Aerts, J.D. Shrout, P.W. Bohn, J.V. Sweedler, Anal. Chem. 86, 2014, 9139–9145. DOI:10.1021/ac5020222

Spatial Organization of Pseudomonas Aeruginosa Biofilms Probed by Combined Matrix-Assisted Laser Desorption Ionization Mass Spectrometry and Confocal Raman Microscopy, R.N. Masyuko, E.J. Lanni, C.M. Driscoll, J.D. Shrout, J.V. Sweedler, P.W. Bohn, Analyst 139, 2014, 5700–5708. DOI:10.1039/c4an00435c

The Ctenophore Genome and the Evolutionary Origins of Neural Systems, L.L. Moroz, K.M. Kocot, M.R. Citarella, S. Dosung, T.P. Norekian, I.S. Povolotskaya, A.P. Grigorenko, C. Dailey, E. Berezikov, K.M. Buckley, A. Ptitsyn, D. Reshetov, K. Mukherjee, T.P. Moroz, Y. Bobkova, F. Yu, V.V. Kapitonov, J. Jurka, Y.V. Bobkov, J.J. Swore, D.O. Girardo, A. Fodor, F. Gusev, R. Sanford, R. Bruders, E. Kittler, C.E. Mills, J.P. Rast, R. Derelle, V.V. Solovyev, F.A. Kondrashov, B.J. Swalla, J.V. Sweedler, E.I. Rogaev, K.M. Halanych, A.B. Kohn, Nature 510, 2014,109–114. DOI:10.1038/nature13400

Fibrinogen-α Chain-derived Peptide is Upregulated in Hippocampus of Rats Exposed to Acute Morphine Injection and Spontaneous Alternation Testing, A.E. Maki, K.A. Morris, K. Catherman, X. Chen, N.G. Hatcher, P.E. Gold, J.V. Sweedler, Pharma. Res. Perspect. 2, 2014, e00037. DOI:10.1002/prp2.37

d-Alanine in the Islets of Langerhans of Rat Pancreas, N. Ota, S.S. Rubakhin, J.V. Sweedler, Biochem. Biophys Res. Commun. 447, 2014, 328–333. DOI:10.1016/j.bbrc.2014.03.153

Application of Capillary Electrophoresis for the Early Diagnosis of Cancer, Z. Yang and J.V. Sweedler, Anal. Bioanal. Chem.406, 2014, 4013–4031. DOI:10.1007/s00216-014-7722-y

Patch Clamp Electrophysiology and Capillary Electrophoresis–Mass Spectrometry Metabolomics for Single Cell Characterization, J.T. Aerts, K.R. Louis, S.R. Crandall, G. Govindaiah, C.L. Cox, J.V. Sweedler, Anal. Chem. 86, 2014, 3203–3208. DOI:10.1021/ac500168d

Prediction and Biochemical Demonstration of a Catabolic Pathway for the Osmoprotectant Proline Betaine, R. Kumar, S. Zhao, M.W. Vetting, B.M. Wood, A. Sakai, K. Cho, J. Solbiati, S.C. Almo, J.V. Sweedler, M.P. Jacobson, J.A. Gerlt, J.E. Cronan, MBio 5, 2014, e00933-00913. DOI:10.1128/mBio.00933-13

Comparing Label-free Quantitative Peptidomics Approaches to Characterize Diurnal Variation of Peptides in the Rat Suprachiasmatic Nucleus, B.R. Southey, J.E. Lee, L. Zamdborg, N. Atkins, Jr., J.W. Mitchell, M. Li, M.U. Gillette, N.L. Kelleher, J.V. Sweedler, Anal. Chem., 86, 2014, 443–452. DOI:10.1021/ac4023378

Small-Volume Analysis of Cell-Cell Signaling Molecules in the Brain, E.V. Romanova, J.T. Aerts, C.A. Croushore, J.V. Sweedler, Neuropsychopharmacology 39, 2014, 50–64. DOI:10.1038/npp.2013.145

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