Marvel Library Compound Collection:

Marvel Library - A Collection of Over 9000 Unique Compounds.

History: The Marvel Storeroom was founded in 1961. It began with the donation of the personal compound collection of Professor Carl Shipp Marvel to the UIUC Chemistry Department upon his retirement in 1961. It served as a free chemical repository for valuable, but no longer needed chemicals to be shared among all members of the Department. This resource was discontinued in 2006, as the questionable quality and identity of much of the library posed a safety risk. Prior to this event, the Hergenrother group went through the Storeroom and salvaged usable compounds with interesting structures.

These compounds were added to the Marvel Library Compound Collection (MLCC), a high-throughput screening (HTS) library in a 384-well format in DMSO maintained by the Hergenrother group. All compounds synthesized by the Hergenrother group are submitted to this respository for storage and screening purposes. The MLCC also contains compounds contributed from various research groups on campus.

The compounds contained in the library are a testament to the diverse, rigorous research that has made the University of Illinois a world leader in the chemical sciences.

plate for Karsons library

The Hergenrother group is eager to share this resource within the scientific community. We retain milligram to gram quantities of all compounds for more rigorous secondary testing, and are happy to part with reasonable quantities of compounds to aid in your research endeavors. We also encourage donations of characterized chemicals with interesting structures to the MLCC. With your donation, we will screen your compounds in our ever-widening array of biochemical assays. Discoveries made in this way will hopefully lead to exciting collaborations and research projects. Make that purified compound sitting in your freezer work for you!

The contents of this library are available as a structure-searchable databases in several formats:

Chemfinder Database (requires Camsoft ChemFinder, unzip and click on marvel.CFW)

SDFile (text-based database (*.sdf) that you can import into Chemfinder, MOE, etc.)

PDF (requires Adobe acrobat reader to view)

Funding:

We are grateful to the following institutions for funding our research:

National Institutes of Health (NIGMS)

National Institutes of Health (NCI)

National Institutes of Health (NIAMS)

National Institutes of Health (NCRR)

National Institutes of Health (NIBIB)

National Science Foundation

Office of Naval Research

Arnold and Mabel Beckman Foundation

Research Corporation

Alfred P. Sloan Foundation

The Camille and Henry Dreyfus Foundation

The American Chemical Society Division of Medicinal Chemistry

Michael J. Fox Foundation

Department of Defense

American Cancer Society

Susan G. Komen Foundation for the Cure

Eli Lilly

Group Jobs:

	Cryocool	Adina Badea
	Group Clean-up Coordination	Amy Larson, Karen Morrison
	Tips and Troughs Ordering	Emilia Calvaresi
	Microscope	Betsy Parkinson
	Karl Fischer	Adina Badea, Karen Morrison
	Autoclave Rotation	Emilia Calvaresi
	Microwave	Michelle Richter, Karen Morrison
	Parallel Synthesizer	Michelle Richter
	Solvent ordering	Claire Knezevic
	SPS/stills	Claire Knezevic, Rob Hicklin
	ISCO machines	Rob Hicklin, Adina Badea
	Website	Bryon Drown, Claire Knezevic
	Computers/Printers	Bryon Drown, Howard Roth
	Social Activities	Rachel Botham
	Plate readers	Betsy Parkinson
	Analyst	Amy Larson
	Benchtop/Microcentrifuge (RAL 249)	Amy Larson
	Floor/Microcentrifuge (RAL 233)	Jessie Peh
	pH meters/electroporator	Jessie Peh
	Shakers/Incubators	Michelle Richter
	Radiation Safety	Adina Badea, Claire Knezevic
	Safety Officer	Betsy Parkinson
	Bio Safety and Lab Tech Liason	Emilia Calvaresi
	-80°C and -20°C freezers	Jessie Peh, Claire Knezevic
	Light box/gel doc	Amy Larson
	Thermocycler	Jessie Peh
	Gel boxes (DNA and protein)	Jessie Peh
	Competent cells	Amy Larson
	Mammalian cells	Emilia Calvaresi, Jessie Peh
	Milli-Q	Michelle Richter
	HPLC	Mike Lambrecht, Michelle Richter
	Balances	Claire Knezevic
	LCMS	Mike Lambrecht, Howard Roth
	Silica Ordering	Howard Roth
	FPLC	Amy Larson
	Fluorscent microscope	Emilia Calvaresi
	Cold Room	Karen Morrison
	Sonicator	Betsy Parkinson
	Antibody Repository	Amy Larson
	Pipette calibration and repair	Jessie Peh
	Plasmid repository	Amy Larson
	NMR Liason	Rob Hicklin

Hergenrother Group Meeting Schedule – Summer 2013

Mondays, 8AM, B124 CLSL

Date	Research	Literature
May 6	Bryon	Jessie
May 13	Hyang-Yeon	Howard
May 20	Howard	Hyang-Yeon
May 27	no meeting
June 3	Isak	Ryan
June 10	Rachel	Mike
June 17	Mike	Isak
June 24	Betsy	Rob
July 1	Rob	Matt
July 8	Claire	Rachel
July 15	Emilia	Claire
July 22	*no meeting*
July 29	Jessie	Emilia
August 5	Michelle	Betsy
August 12	Matt	Michelle
August 19	Ryan	Bryon

Other UIUC Affiliations:

We are affiliated with various other departments and programs on campus:

Department of Chemistry

Department of Biochemistry

School of Molecular and Cellular Biology

Biotechnology Center

Initiative on Aging

Center for Biophysics and Computational Biology

Cell and Molecular Biology Training Grant

Center of Advanced Materials for Purification of Water

Institute for Genomic Biology

Center for Advanced Study

The Center for Nanoscale Chemical-Electrical-Mechanical Manufacturing Systems

Templates:

Instructions: Right click on the link and save. Open the file and fill in your information. Then, click "Save As..." and change document type to "document template." This should save the file, by default, to "C:\Documents and Settings\Username\Application Data\Microsoft\Templates" (where "username" is your computer logon name). Make sure it saves to this location.

In MS Word, now you can click on "New..." and you should be able to see these templates in general templates.

General Templates:

SCS Order Form
ChemTrack solvent disposal form
Mass Spec form

Labels: See Ben for labels.

The Hergenrother Lab uses the following printable labels:

Avery 5160 (1" x 2 5/8") - in stockroom
Avery 5162 (1 1/3" x 4") - in stockroom
1/2" diameter Microtube tough spots (reorder: Midwest Scientific Reorder No. "SPOT 2000")

The above templates are useful for when you only need to print a few labels. simpley open the file and type in the appropriate boxes. Insert your label sheet in the manual feeder and hit print. MAKE SURE you're not printing in a box that corresponds to a space on your label sheet that no longer has a label.

For whole sheets of labels, you need to do a "mail merge." This enables you to print a whole sheet of the same label, or take data from an Excel file and make a series of labels. In MS Word, click, "Tools > Letters and Mailings > Envelopes and Labels" to open the mail merge wizard. If you can't figure it out, ask Ben.

Dissertations:

2012

Dr. Timothy Alan Flood, Jr. -- "Advances in High-Throughput Screening: Better Compounds, Novel Targets, Enhanced Sensors"

2011

Dr. Joseph Bair -- "The Development of Deoxynyboquinone as a Personalized Anticancer Compound"
Dr. Quinn Peterson -- "Small Molecule Activators of Procaspase-3 as an Anticancer Strategy"
Dr. Rahul Palchaudhuri -- "Development and Mechanistic Characterization of Novel Small Molecules as Cancer Therapeutics"
Dr. Diana West -- "The Discovery and Characterization of Anticancer Procaspase-Activating Compounds"
Dr. Kristin Finch -- "The Discovery of Small Molecule Inhibitors of Poly(ADP-Ribose) Mediated Cell Death"
Dr. Nora Wang -- "The Identification and Characterization of Novel Antibacterial Compounds via Target-Based and Whole Cell Screening Approaches"

2010

Dr. Elizabeth Moritz Halvorsen-- "The Prevalence of Toxin-Antitoxin Systems and Their Tractability as Novel Antimicrobial Targets"
Dr. Mirth T. Hoyt -- "The Anticancer Mode of Action of the Quinone Natural Product Cribostatin 6"
Dr. James T. Heeres -- "High-Throughput Detection of Protein—Protein and Protein—DNA Interactions Via Photonic Crystal Biosensors: Applications to Apoptosis Inducing Factor"

2009

Dr. Todd Meyer -- "Selective Targeting of RNA with Small Molecules: Design and Synthesis of Ligands for Selective Binding to RNA Bulges and Hairpin Loops"
Dr. Benjamin Leslie -- "Small Molecule Modulation of the Cell Cycle: Discovery of Anticancer Compounds that Induce G1- and M-Phase Cell Cycle Arrest and Characterization of Their Modes of Action"

2008

Dr. Christina Thompson -- "The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs"
Dr. Robin S. Dothager -- "Strategies for the Selective Treatment of Cancer, Including the Identification and Mechanism of Action of Compounds that Induce G1 Cell Cycle Arrest"
Dr. Amanda C. Nottbohm -- "Chemical Tools to Monitor and Inhibit Poly(ADP-Ribosyl)ation"

2007

Dr. David Goode -- "Small Molecule Modulation of Caspase Enzymatic Activity"
Dr. Jason R. Thomas -- "Toward the Therapies of Tomorrow: Selective RNA-Binding Small Molecules and Cytoprotective Strategies for ROS-Mediated Disease States"

2006

Dr. Dinty J. Musk -- "Discovery and Characterization of Small Molecule Inhibitors of Biofilm Formation in Pseudomonas aeruginosa"
Dr. Karson S. Putt -- "The Modulation of Life and Death: Small Molecule Activators and Inhibitors of Necrotic and Apoptotic Pathways"
Dr. Vitaliy Nesterenko -- "Synthesis of Biologically Active Cytoprotective and Anticancer Small Molecules"