Original Research Article
Review Article
Mitchell, D.A.; Lee, S.W.; Pence, M.A.; Markley, A.L.; Limm, J.D.; Nizet, V.; Dixon, J.E. “Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S.” J. Biol. Chem., 284: 13004-13012 (2009). doi:10.1074/jbc.M900802200
Identification of residues for synthetase binding and cytolytic activity for the streptolysin S precursor peptide.
Ghosh, A.; Mitchell, D.A.; Chanda, A.; Ryabov, A.D.; Popescu, D.L.; Upham, E.; Collins, T.J. “Catalase-peroxidase activity of iron(III)-TAML activators of hydrogen peroxide.” J. Am. Chem. Soc., 130: 15116-15126 (2008). doi:10.1021/ja8043689
Lee, S.W.; Mitchell, D.A.; Markley, A.L.; Hensler, M.E.; Gonzalez, D.; Wohlrab, A.; Dorrestein, P.C.; Nizet, V.; Dixon, J.E. “Discovery of a widely distributed toxin biosynthetic gene cluster.” Proc. Natl. Acad. Sci. USA USA, 105: 5879-5884 (2008). doi:10.1073/pnas.0801338105
The in vitro reconstitution of streptolysin S biosynthesis and the bioinformatics-based discovery of the linear azol(in)e-containing peptide natural product family.
Mitchell, D.A.; Morton, S.U.; Fernhoff, N.B.; Marletta, M.A. “Thioredoxin is required for S-nitrosation of procaspase-3 and inhibits apoptosis in Jurkat cells.” Proc. Natl. Acad. Sci. USA USA, 104: 11609-11614 (2007). doi:10.1073/pnas.0704898104
Mitchell, D.A.; Marletta, M.A.; Michel, T. “Effects of S-nitrosation of nitric oxide synthase isoforms.” Adv. Exp. Biol., Nitric Oxide 1, Ch. 7. Elsevier Publishing
Chahbane, N.; Popescu, D.L.; Mitchell, D.A.; Chanda, A.; Lenoir, D.; Ryabov, A.D.; Schramm, K.W.; Collins, T.J. “Fe(III)-TAML catalyzed green oxidative degradation of the azo dye Orange II by H2O2 and organic peroxides: products, toxicity, kinetics, and mechanisms.” Green Chem., 9: 1-10 (2007). doi:10.1039/B604990G
Mitchell, D.A.; Morton, S.U.; Marletta, M.A. “Design and characterization of an active site selective caspase-3 transnitrosating agent.” ACS Chem. Biol., 1: 659-665 (2006). doi:10.1021/cb600393x
Erwin, P.A.; Mitchell, D.A.; Sartoretto, J.; Marletta, M.A.; Michel, T. “Subcellular targeting and differential S-nitrosylation of endothelial nitric oxide synthase.” J. Biol. Chem., 281: 151-157 (2006). doi:10.1074/jbc.M510421200
Mitchell, D.A.; Marletta, M.A. “Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine.” Nat. Chem. Biol., 1: 154-158 (2005). doi:10.1038/nchembio720
Mitchell, D.A.; Erwin, P.A.; Michel, T.; Marletta, M.A. “S-Nitrosation and regulation of inducible nitric oxide synthase.” Biochemistry, 44: 4636-4647 (2005). doi:10.1021/bi0474463
Lazo, J.S.; Nemoto, K.; Pestell, K.E.; Cooley, K.; Southwick, E.C.; Mitchell, D.A.; Furey, W.; Gussio, R.; Zaharevitz, D.W.; Joo, B.; Wipf, P. “Identification of a potent and selective pharmacophore for Cdc25 dual specificity phosphatase inhibitors.” Mol. Pharmacol., 61: 720-728 (2002). doi:10.1124/mol.61.4.720